Read e-book online Tritium and other radionuclide labeled organic compounds PDF

By National Council on Radiation Protection and Measurements

ISBN-10: 0913392472

ISBN-13: 9780913392478

ISBN-10: 1435629272

ISBN-13: 9781435629271

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Read or Download Tritium and other radionuclide labeled organic compounds incorporated in genetic material: Recommendations of the National Council on Radiation Protection and Measurements (NCRP report ; no. 63) PDF

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Extra info for Tritium and other radionuclide labeled organic compounds incorporated in genetic material: Recommendations of the National Council on Radiation Protection and Measurements (NCRP report ; no. 63)

Sample text

This is about 14 times higher than the dose limit of 5 rad. 07 must be applied. Hence, it it is suggested that the limit for continuous exposure be For the same amounts of 3H-thymidine injected or ingested, 5 times as much is incorporated into DNA after injection as after ingestion. 0 pCi/h for chronic ingestion. 6 Other Tritium-Labeled DNA Precursors Deoxycytidine, in addition to thymidine, is an immediate precursor that is also specifically incorporated into DNA. In order to calculate dose, it is assumed that the metabolism of thyrnidine and of deoxycytidine is similar.

The basic objective in this report is to keep the average radiation dose to stem cell nuclei below 5 rem per annum even though only a fraction of the stem cells will be labeled after a single intravenous injection or ingestion of radionuclide DNA precursors. If there is continued intake by injection or ingestion, almost all of the stem cells will become labeled with time depending on the kinetics of their turnover. When, as described earlier, a sufficient amount of %-thymidine is given continuously so that almost all stem cells will be labeled and receiving an annual dose of 5 rem, there is still a wide divergence from average tissue dose.

For 35S distributed in tissue, one 35Sdecay delivers a dose that is proportional to the beta energy, or eight times the dose absorbed per tritium decay (Section 4). It is recommended that the maximum permissible body burden, 90 pCi in the critical organ, testis, and 400 pCi for the total body, given in NCRP Report No. 22 be observed (NCRP, 1959). 9. Iodine-131 and Iodine-125- Labeled Precursors for DNA 131 I and "51 are discussed because both are used as labels for 5-iodo2'-deoxyuridine (IUdR) that is incorporated into DNA in the place of thymidine.

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Tritium and other radionuclide labeled organic compounds incorporated in genetic material: Recommendations of the National Council on Radiation Protection and Measurements (NCRP report ; no. 63) by National Council on Radiation Protection and Measurements


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