Download e-book for iPad: The Gene Wars: Science, Politics, And The Human Genome by Robert Cook-Deegan MD

By Robert Cook-Deegan MD

ISBN-10: 0393313999

ISBN-13: 9780393313994

I initially learn this e-book for a school direction in regards to the ethics of genetics. it truly is whatever everyone within the organic or ordinary sciences may still learn, however it can also be precious for an individual drawn to genetics. it's essentially concerning the politics and ethics which encompass all genetic concerns. Cook-Deegan explains the rudiments of genetics in an easy to appreciate demeanour, after which launches into an in-depth exam of the politics of genetics. extra is going on behind the curtain of organic technological know-how than you'll ever think. within the coming years genetics and the moral matters surrounding genetics are going to turn into extremely important in medication, pharmaceutical learn, and felony forensics. now not only a category for technological know-how majors, genetics may perhaps input your existence in methods you by no means anticipated. Cook-Deegan's e-book can definately train in addition to entertain.

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Extra resources for The Gene Wars: Science, Politics, And The Human Genome

Sample text

Each family pedigree took immense effort to construct and to check. Agreeing to share access to these pedigrees entailed a degree of cooperation in map construction often overlooked in the race to find individual disease-associated genes by using the map. 71 The collaborative arrangement had its weaknesses and tensions, but it outlived the public clashes to unify the efforts. When NIH joined the effort in 1990, and with the emergence of a high-technology French collaboration at more or less the same time, progress was even more rapid.

It was a long way from determining chromosomal location by RFLP mapping to isolating a gene. The work was tedious, methods were unreliable, and they often proved inadequate to the task. Finding genes required better methods to study DNA from a given chromosomal region. To move expeditiously from approximate chromosomal location to actual gene required a different kind of map—a physical map. Physical mapping bridged the gap between genetic linkage and DNA sequence, an important intermediate step.

The pieces were in place to construct a map of the human chromosomes, but learning how to combine the various techniques fruitfully required further insight. A series of papers on experiments with viruses and yeast showed how genetic linkage mapping might be accomplished in humans. 39 In a series of experiments that presaged the idea of the human genome project, yeast DNA was cut into fragments using restriction enzymes, which recognized specific DNA sequences. 40 DNA fragments containing two normal genes were compared with a mutant version of the 34 The GENE WARS same gene to find a change in a single DNA base pair.

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The Gene Wars: Science, Politics, And The Human Genome by Robert Cook-Deegan MD

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