By Nancy J. Wesensten
Sleep Deprivation: Stimulant medicinal drugs and Cognition offers a evaluation, synthesis and research of the clinical literature pertaining to stimulant medicines and neurobehavioral functionality, with an emphasis on seriously comparing the sensible software of those brokers for conserving cognitive functionality and application in sleep-deprived (but another way fit) members. The publication explores the character of sleep loss-induced cognitive deficits, neurophysiologic foundation of those deficits, relative efficacy and obstacles of assorted interventions (including non-pharmacological), and implications for utilising those interventions in operational environments (commercial and military). Readers of this quantity will achieve a operating wisdom of: • Mechanisms contributing to sleep loss-induced cognitive deficits; • Differential results of stimulant compounds on a variety of facets of cognition; • concerns (e.g., abuse legal responsibility) while employing stimulant interventions in operational settings; • present country and destiny instructions for together with stimulants in complete fatigue-management thoughts. this article is essential analyzing for researchers and trainees in sleep and psychopharmacology
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Extra info for Sleep deprivation, stimulant medications, and cognition
As illustrated earlier, the effects of SD on sustained attention and risky decision-making appear uncorrelated. Yet maintaining both may be important in missioncritical situations. As such, investigators using neuroimaging techniques would do well to concurrently evaluate a mixture of cognitive domains across several tests. Appropriately phenotyping test subjects into SD-vulnerable and SD-non-vulnerable on the characteristics of interest prior to conducting a pharmacological fMRI experiment might be a cost-effective means to reduce the number of test subjects necessary to ascertain the efﬁcacy of a countermeasure.
90] Caldwell JA, Prazinko B, Caldwell JL. Body posture affects electroencephalographic activity and psychomotor vigilance task performance in sleepdeprived subjects. Clin Neurophysiol 2003; 114(1): 23–31.  Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer’s disease. NeuroRx 2005; 2(2): 348–60.  Jack CR Jr, Shiung MM, Gunter JL, et al. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD.
Dopaminergic neurons are localized in the substantia nigra (SN) and ventral tegmental area (VTA), two adjacent nuclei in the ventral midbrain. The SN population is associated with the striatal control of voluntary movement (and the movement disorder Parkinson’s disease, when these neurons are absent). The VTA population is associated with mediation of the rewarding aspects of environmental stimuli (such as drugs of abuse) via projections to the ventral striatum and nucleus accumbens. It remains uncertain, though, how these two populations are speciﬁcally involved in wakefulness and alertness/vigilance.
Sleep deprivation, stimulant medications, and cognition by Nancy J. Wesensten