Regenerative Medicine for the Inner Ear by Juichi Ito PDF

By Juichi Ito

ISBN-10: 4431548610

ISBN-13: 9784431548614

ISBN-10: 4431548629

ISBN-13: 9784431548621

The learn defined during this ebook represents vital steps towards realizing the advance of internal ear drugs and new views in regenerative drugs, together with efficacy in cochlear implants and diverse different remedies. The e-book depicts the mechanisms that underlie internal ear illnesses, their experimental versions, and recommendations for brand spanking new techniques to regard their signs. besides, the intriguing destiny clients for facing the quite common challenge of internal ear illnesses are defined. those issues happen between many folks and comprise sensorineural listening to loss (SNHL), unexpected deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s ailment. In Japan on my own, there are greater than 6 million deaf sufferers together with people with middle-range deafness. there's at the moment no potent therapy, and whatever the underlying reason, the wear has been thought of irreversible. in spite of the fact that, the result of fresh study convey that those sufferers truly can get well. The research of hair cells, spiral ganglion neurons, and stem cells for internal ear ailments akin to SNHL, tinnitus, dizziness, and vertigo is on the leading edge of regenerative drugs and will offer recommendations to a couple of those difficulties. the data provided the following makes this booklet a important specialist reference paintings for all medical professionals and researchers within the box of otolaryngology who specialize in regenerative remedies for internal ear diseases.

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Nishimura K, Nakagawa T, Sakamoto T, Ito J. Fates of murine pluripotent stem cell-derived neural progenitors following transplantation into mouse cochleae. Cell Transplant. 2012;21 (4):763–71. 25. Inaoka T, Shintaku H, Nakagawa T, Kawano S, Ogita H, Sakamoto T, et al. Piezoelectric materials mimic the function of the cochlear sensory epithelium. Proc Natl Acad Sci U S A. 2011;108(45):18390–5. Chapter 3 Hair Cell Norio Yamamoto Abstract Hair cells are the main components of the inner ears that facilitate mechano-electrical transduction to perceive sound or change in body position.

7. Suckfuell M, Canis M, Strieth S, Scherer H, Haisch A. Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study. Acta Otolaryngol. 2007;127(9):938–42. 8. Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, et al. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Med. 2010;8:76. 9. Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, et al.

There are a number of different links in stereocilia, tip links, lateral links, and ankle links [37, 38]. The distribution of links within the hair bundle and the types of link present can vary according to hair cell type and position within a given sensory organ, in the same way that the shape and form of the hair bundle can vary from one organ to another and within the same organ. During maturation of stereocilia, rootlets insert into the cuticular plate and adopt a tapered shape, enhancing the 34 T.

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Regenerative Medicine for the Inner Ear by Juichi Ito

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