By Peter Panus, Bertram Katzung, Erin Jobst, Suzanne Tinsley, Susan Masters, Anthony Trevor
The 1st pharmacology e-book for actual therapists written through actual therapists and PhD pharmacologists in accordance with the vintage Katzung's easy and scientific Pharmacology, this ground-breaking booklet illuminates the ever-expanding function of pharmacology in rehabilitation perform. In it you will discover unequalled insights at the complete variety of pharmacology issues, from drug receptor pharmacodynamics and basic anesthetics, to melanoma chemotherapy-all instructed from the vantage aspect of the authors' wide first-hand adventure. beneficial properties: entire, updated descriptions of universal antagonistic drug reactions correct to actual remedy factors of ways medicinal drugs can very likely disrupt sensible and medical results, in addition to corresponding actual therapy-based recommendations to beat those matters “Problem-Oriented sufferer stories” (POPS), which function the sufferer because the point of interest of the case instead of drug remedy itself “Preparations to be had” packing containers that offer at-a-glance summaries of the medicine to be had to regard particular stipulations and problems word list of need-to-know phrases
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Additional info for Pharmacology for the Physical Therapist
In t h e GI tract, weak acids can be passively absorbed i n the sto mach where the pH i s aro und 1 to 3 and these acids a re non ionized (Figure 3-1a), but weak b ases are very poorly When d rugs ente r the body at s i tes remote from the ta rget tissue or o rgan, they req u ire t ransport by the cir c u l a tio n to t h e intended site of ac tion. To ente r the bloodstrea m, a drug must b e abso rbed ftom its s ite of adm i nistrati o n. 4 • Stomach lumen pH 1-3 entry of the d rug into the b o dy.
Drugs to less lipid-soluble and more readily excreted To ensure elimination of pharmacologically active for fo rm s . eign chemicals as well as to terminate the action of many end ogenous subsrances, metabolic parhways are . available to alter rheir activity and increase their sus Sites of Drug Biotransformation ceptibility to excrerion. Biotran sform arion is a meta The most important organ for biorransformation is bolic mechanism used to decre ase rhe acrivity of the liver. The exogenous and endogenous chemical com pounds.
The size of the organ determines the concentration gradient between blood and the organ. For example, skeletal muscle can take up a large amount of drug because the concentration in the muscle tissue remains low, and the blood to tissue gradient high. This gradient contin ues even after relatively large amounts of drug have been transferred because skeletal muscle is a very large organ. In contrast, because the brain is smaller, distri bution of a smaller amount of drug into it wiJl raise the tissue concentration and reduce the blood to tissue concentration gradient to zero.
Pharmacology for the Physical Therapist by Peter Panus, Bertram Katzung, Erin Jobst, Suzanne Tinsley, Susan Masters, Anthony Trevor