By Peter A. Calabresi, Laura J. Balcer, Elliot M. Frohman
Optical coherence tomography [OCT] presents tissue morphology imagery at a lot larger solution than different imaging modalities equivalent to MRI or ultrasound, and the machines are relatively more affordable. it's a simple strategy to practice; is non-ionizing, and for that reason secure. those merits are riding a swift transformation of OCT, from its primary software as a study device, into an extension of the 'neurological exam' in regimen workplace perform. initially utilized in assessing the severity of tissue harm and diagnosis of a number of sclerosis and numerous neuro-ophthalmic stipulations, OCT is more and more utilized in different neurological issues reminiscent of Parkinson's disorder, ALS, and Alzheimer's ailment. This e-book is the 1st finished overview of using OCT in neurological ailments. The assurance incorporates a description of the process and its usage in a number of neurologic stipulations. crucial analyzing for neurologists, neuro-ophthalmologists, and neuroradiologists in need of an introductory account of the scientific purposes of OCT.
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Additional resources for Optical Coherence Tomography in Neurologic Diseases
Recurrent attacks are associated with further reductions in vision [23, 60, 63–65]. Ratchford and colleagues  studied a small cohort of patients with NMO. When compared with patients with multiple sclerosis, optic neuritis in NMO resulted in more severe RNFL thinning and macular volume loss, and there was more visual loss than in multiple sclerosis-associated optic neuritis. Using multivariate linear regression, they estimated that the initial attack of optic neuritis caused, on average, a 31µm reduction in the nerve ﬁber layer thickness, and each further attack resulted in approximately 10 µm of thinning.
Macular volume encompasses the whole retina from the vitreoretinal interface to the retinal pigment epithelium, and a reduction in volume likely reﬂects loss of other components of the retina rather than simply the RNFL. We have observed small degrees of whole macular swelling in patients in the early phases of acute idiopathic optic neuritis, to a lesser extent than is visible in the RNFL, and it is usually only notable when the aﬀected eye is compared to the unaﬀected fellow eye. Chapter 4: Optical coherence tomography in acute optic neuritis Gelﬂand and colleagues  reported the appearance of macular microcysts in the retina of patients with multiple sclerosis.
Although optic neuritis can occur at any age, the peak incidence is in the fourth decade of life, and women outnumber men approximately three to one [3, 4]. Most commonly, optic neuritis is unilateral. The usual symptoms of optic neuritis are periorbital pain (which may precede the onset of visual loss noted by the patient), pain on eye movement, and reduction in vision (both central and peripheral). Patients with optic neuritis may also experience positive visual phenomena (phosphenes), usually provoked by eye movement.
Optical Coherence Tomography in Neurologic Diseases by Peter A. Calabresi, Laura J. Balcer, Elliot M. Frohman