By Andrés Aguilera, Rodney Rothstein
This paintings deals a desirable perception right into a an important genetic technique. Recombination is, without difficulty, the most very important issues in modern biology. This publication is a unconditionally complete therapy of the topic, summarizing all present perspectives at the subject and even as placing them into context. It offers in-depth and updated research of the bankruptcy subject matters, and has been written through foreign specialists within the box.
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Extra resources for Molecular Genetics of Recombination
Alonso (formerly RecB3), SbcC, SbcD, SbcC2 (YhaN), SbcD2 (YhaO)], in the maintenance of separated chromosomes with the proper structure and supercoiling levels (Smc-ScpA-ScpB complex, Hbsu, LrpC, Topo I, Topo II, Topo III and Topo IV), and in sister chromosome separation [RipX-CodV working in concert at dif] (Fernandez et al. 1997; 2000; Champoux 2001; Sherratt 2003; our unpublished results; Lopez et al. 2005; Lopez-Torrejon et al. 2006; Table 2). g. g. g. g. ligD, ku, topB, mutS2, sbcC2 and sbcD2 genes).
Guzman, personal communication). It does not occur in mutants impaired for replication initiation (Seigneur et al. 1998), in mutants impaired for replicative topoisomerases (Grompone et al. 2003, 2004a), and at physiological replication arrest sites (Ter, Bidnenko et al. 2002), which implies that forks arrested by different means differ in their structure or by the presence of different sets of remaining associated replication proteins. In vitro, RecA and RecG were shown to be able to reverse DNA molecules that mimic fork structures (McGlynn and Lloyd 2000; Robu et al.
Ann Rev Biophysics Biophysic Chem 20:539575 Kuzminov A (1995) Collapse and repair of replication forks in Escherichia coli. Mol Microbiol 16:373-384 22 Bénédicte Michel, Zeynep Baharoglu, and Roxane Lestini Kuzminov A (1999) Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda. Microbiol Mol Biol Rev 63:751-813 Kuzminov A (2001) Single-strand interruptions in replicating chromosomes cause doublestrand breaks. Proc Natl Acad Sci USA 98:8241-8246 Lee BI, Kim KH, Park SJ, Eom SH, Song HK, Suh SW (2004) Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair.
Molecular Genetics of Recombination by Andrés Aguilera, Rodney Rothstein