By Gustavo Maroni
Univ. of North Carolina, Chapel Hill. Textbook for undergraduates and graduates conversant in uncomplicated genetics. Assumes wisdom of meiosis and Mendelian genetics. issues succeed: How will we determine trait is hereditary? and the way can the houses of a trait be defined by way of the underlying molecular reasons? End-of-chapter workouts are integrated. Softcover.
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Extra resources for Molecular and Genetic Analysis of Human Traits
FIGURE 2-1. Family carrying two different genetic forms of hearing loss. Freeman and Company. ” These are instead quantitative traits for which there seems to be a continuum of expression within the normal population. Classical examples include height and weight. Physiological parameters of great public health significance such as blood pressure or serum cholesterol levels exhibit similar, continuously varymg, patterns. In some cases, the variability may be due entirely to environmental conditions, but more typically quantitative traits result from the combined effects of genetics and the environment.
Et al. A polymorphic DNA marker genetically linked to Huntington's disease. ) FIGURE 1-18. Branch of the Venezuelan family, indicating the haplotype and Huntington's disease status for each individual used for LOD score analysis. Haplotype designations are as in Figures 1-16and 1-17. (Redrawn with permission from Fig. A polymorphic DNA marker genetically linked to Huntington's disease. ) Molecular and Genetic Analysis of Human Traits 27 TABLE 1-6. Linkage of the Huntington's disease gene to the G8 probe and the MIN blood group gene, summary of LOD scores.
Variable Expressivity and Incomplete Penetrance Variable expressivity refers to differences in severity of the condition observed in individuals having the same genotype, so the classification of phenotypes may be confusing because of the apparent existence of multiple classes. For example, one might propose that the mild cases are due to heterorygosis for a mutation and the more severe cases are due to homozygosis when both have, in fact, the same genotype. The penetrance of a trait is defined as the fraction of individuals of a certain genotype who express a particular phenotype; incomplete penetrance refers to those cases where that fraction is less than one.
Molecular and Genetic Analysis of Human Traits by Gustavo Maroni