New PDF release: Hypothermia and Cerebral Ischemia: Mechanisms and Clinical

By Carolina M. Maier, Gary K. Steinberg

ISBN-10: 089603660X

ISBN-13: 9780896036604

ISBN-10: 1592596533

ISBN-13: 9781592596539

A accomplished evaluate of the medical and scientific experiences that experience resulted in the resurgence of curiosity in hypothermia as a neuroprotective technique within the remedy of stroke and disturbing mind harm. themes of unique value comprise intraoperative and extensive care administration of hypothermia-treated sufferers, a severe examine the possibility of combining hypothermia with pharmacotherapy, and an replace at the most modern technological advances that experience made hypothermic remedy attainable in modern-day scientific atmosphere.

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Several questions arose: How quickly must hypothermia be initiated after ischemia to be neuroprotective? For how long and to what depth should it be administered? Is the resulting neuroprotection temporary or permanent? Using a model of 10-min normothermic global forebrain ischemia by the two-vessel occlusion model, we compared the neuropathological outcome when cranial cooling to 30°C was begun at either 5 or 30 min following the ischemic insult, and was maintained for 3 h (38). In these initial studies, in which only a 3-d survival was permitted, 50% protection of hippocampal CA1 pyramidal neurons was achieved when cooling was begun at 5 min postischemia, but cooling was ineffective if deferred until 30 min.

J. Neurochem. 24, 311–316. 13. Rosomoff H. L. (1957) Hypothermia and cerebral vascular lesions. II. Experimental middle cerebral artery interruption followed by induction of hypothermia. AMA Arch. Neurol. Psychiatry 78, 454–464. 14. Rosomoff H. L. (1959) Experimental brain injury during hypothermia. J. Neurosurg. 16, 177–187. 15. Connoly J. , Boyd R. , and Calvin J. W. (1962) The protective effect of hypothermia in cerebral ischemia: experimental and clinical application by selective brain cooling in the human.

D. (1998) The influence of altered brain temperature in cerebral ischemia. In Cerebrovascular Disease: Pathophysiology, Diagnosis and Management (Ginsberg M. D. ), Blackwell Science, Malden, pp. 287–307. 32 Ginsberg and Belayev 11. Rosomoff H. L. and Holaday D. A. (1954) Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am. J. Physiol. 179, 85–88. 12. , and Siesjo B. K. (1975) The effect of induced hypothermia upon oxygen consumption in the rat brain. J. Neurochem. 24, 311–316.

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Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications by Carolina M. Maier, Gary K. Steinberg

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