New PDF release: Gamma Knife Brain Surgery (Progress in Neurological Surgery

By L. Dade Lunsford, D. Kondziolka, John C., M.D. Flickinger

ISBN-10: 3805566379

ISBN-13: 9783805566377

This paintings appears on the use of gamma knife expertise in surgical procedure, its radiobiologic issues, ideas of dose prescription, and makes use of in vascular radiosurgery and benign tumour radiosurgery.

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Additional info for Gamma Knife Brain Surgery (Progress in Neurological Surgery Volume 14)

Sample text

Predict facial weakness, numbness, and hearing loss after radiosurgery [3]. Figure 6 shows one family of dose-response curves for facial neuropathy. We do not routinely consult these risk-prediction curves for help in dose prescription. Our current policy is to treat acoustic tumors to a minimum tumor dose of 12–14 Gy depending upon the size of the tumor and how important the goals of hearing preservation and avoidance of facial or trigeminal neuropathies are in each individual patient. Higher doses may even be considered in patients with tumors that recur following prior resection who have no hearing and facial weakness and/or numbness.

When this response becomes chronic, fibroblasts replace much of the mass of the AVM. Szeifert et al. [42] showed that myofibroblasts could be identified within the AVM and may provide some element of contractility to the obliteration process. Schneider et al. [36] reported a recent review of the histopathology of AVM radiosurgery from 9 specimens 10–60 months after irradiation. In most patients where histology has been obtained, only subtotal obliteration had been found (hence the need for AVM removal).

Kondziolka D, Somaza S, Martinez AJ, et al: Radioprotective effects of the 21-aminosteroid U-74389G for stereotactic radiosurgery. Neurosurgery 1997;41:203–208. Larson DA: Radiosurgery and fractionation; in Kondziolka D (ed): Radiosurgery 1995. Radiosurgery. Basel, Karger, 1996, vol 1, pp 261–267. Larson DA, Flickinger JC, Loeffler JS: The radiobiology of radiosurgery. Int J Radiat Oncol Biol Phys 1993;25:557–561. Larsson B, Leksell L, Rexed B, et al: The high-energy proton beam as a neurosurgical tool.

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Gamma Knife Brain Surgery (Progress in Neurological Surgery Volume 14) by L. Dade Lunsford, D. Kondziolka, John C., M.D. Flickinger


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