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By John L Jinks

The Prentice-Hall starting place of contemporary Genetics sequence offers the proof upon which present genetic proposal relies. it really is neither a heritage nor a survey of all genetic wisdom.

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Additional resources for Extrachromosomal Inheritance (Prentice-Hall Foundations of Modern Genetics)

Sample text

Of course, the success of such an approach depends strongly on the means and accuracy with which functional elements can be identified. Further, traditional, low-throughput sequencing technologies place severe limitations on the number of individuals and the number of genomic regions that can be resequenced in an economically feasible way. , next-gen) technologies have emerged, promising inexpensive and efficient sequencing of large amounts of genomic DNA as a follow-up to GWA studies (2). While this advance will enable researchers to find many more novel sequence variants than previously possible, it seems likely that the bottleneck in causal variant identification will move from sequencing to functional validation, a process for which databases of functional genomic elements will also prove useful in prioritizing specific variants for testing.

Taking TCF7L2 as a specific example, the association between variants in this gene and type 2 diabetes Statistical Issues in Gene Association Studies 31 sĀ­ usceptibility gene has been replicated in almost every population examined, except for the Pima Indians (123) and some Chinese populations (124). Therefore, one cannot readily assume that because association between a genetic variant and disease or quantitative trait is replicated in one population, the same association should exist in other populations.

Knowler WC, Williams WC, Pettitt DJ, Steinberg AG (1988) Gm 3;5, 13, 14 and type 2 diabetes mellitus: an association in American Indians with genetic admixture. Am J Hum Genet 43:520ā€“526 95. Abecasis GR, Cookson WO, Cardon LR (2000) Pedigree tests of transmission disequilibrium. Eur J Hum Genet 8:545ā€“551 96. Martin ES, Monks SA, Warren LL, Kaplan NL (2000) A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet 67:146ā€“154 97. Lange C, Laird NM (2002) Power calculations for a general class of family-based association tests: dichotomous traits.

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Extrachromosomal Inheritance (Prentice-Hall Foundations of Modern Genetics) by John L Jinks


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