By Alfred A. Bove (Eds.)
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Extra resources for Exercise Medicine. Physiological Principles and Clinical Applications
Constant stroke volume occurs by facilitating ventricular contractility to reduce end-systolic volume. Peripheral vascular mechanisms of exercise involve (1) reduced total peripheral resistance via local metabolic factors to prevent severe elevations in mean arterial blood pressure, and (2) sympathetic nervous system mediated reduction in venous capacitance in concert with muscle and respiratory " p u m p " mechanisms promote venous return to the heart. In short, circulatory adjustments during exercise are qualitatively and quantitatively appropriate to meet the metabolic demands imposed on the organism.
Several systems are present peripherally that supply sensory input to the brainstem respiratory centers. The carotid and aortic bodies are chemoreceptors located in the arterial circulation that respond to decreased oxygen tension and increased carbon dioxide tension in the arterial blood that bathes these nests of cells. Whereas hypoxemia and hypercarbia individually cause the carotid and aortic bodies to increase ventilation, both in combination result in an even greater ventilatory response.
2, pp. 9 3 9 - 9 7 8 . Am. Physiol. C. 9. Âstrand, P. O . , and Rodahl, Κ. (1977). , p. 233. McGraw-Hill, New York. 10. Demsey, J. Α . , and Rankin, J. (1967). Physiologic adaptations of gas transport systems to muscular work in health and disease. Am. J. Phys. Med. 46, 5 8 2 - 6 4 7 . 11. , and Nielsen, M. (1960). Alveolo-arterial gas exchange at rest and during work at different 02-tensions. Acta Physiol. Scand. 50, 153-166. 12. Gledhill, N . , Froese, A. B . , and Dempsey, J. A. (1977). Ventilation to perfusion distribution during health and disease.
Exercise Medicine. Physiological Principles and Clinical Applications by Alfred A. Bove (Eds.)