Epigenetics in Human Disease by Trygve Tollefsbol PDF

By Trygve Tollefsbol

ISBN-10: 0123884152

ISBN-13: 9780123884152

Epigenetics is among the quickest becoming fields of sciences, illuminating experiences of human ailments by way of having a look past genetic makeup and acknowledging that out of doors components play a job in gene expression. The aim of this quantity is to focus on these illnesses or stipulations for which now we have complex wisdom of epigenetic components corresponding to melanoma, autoimmune problems and getting older in addition to those who are yielding interesting breakthroughs in epigenetics comparable to diabetes, neurobiological issues and heart problems. the place acceptable, makes an attempt are made not to merely element the position of epigenetics within the etiology, development, analysis and diagnosis of those illnesses, but in addition novel epigenetic techniques to the remedy of those ailments. Chapters also are provided on human imprinting problems, respiration illnesses, infectious ailments and gynecological and reproductive illnesses. considering epigenetics performs a big function within the getting older strategy, advances within the epigenetics of getting older are hugely proper to many age-related human ailments. consequently, this quantity closes with chapters on getting older epigenetics and breakthroughs which were made to hold up the getting older strategy via epigenetic ways. With its translational concentration, this e-book will function important reference for either easy scientists and clinicians alike.

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Furthermore, aberrant DNA hypomethylation can also induce activation of oncogenes and loss of imprinting. However, a more widely recognized epigenetic change in human cancers is DNA hypermethylation at the CpG islands of promoters that silences specific genes, including tumor-suppressor genes [20] such as CDKN2A (cyclin-dependent kinase inhibitor 2A), CDKN2B (cyclin-dependent kinase inhibitor 2B), TP73 (tumor protein p73), MLH1 (mutL homolog 1), Apc (adenomatosis polyposis coli), BRCA1 (breast cancer 1), MGMT (O-6-methylguanine-DNA methyltransferase), VHL (von Hippel-Lindau tumor-suppressor), GSTP1 (glutathione S-transferase pi 1), CDH1 (cadherin 1) and DAPK1 (death-associated protein kinase 1).

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In the future, this will be a promising strategy for epigenetic analysis. 7 OVERVIEW OF RECENT EPIGENETIC GENOME-WIDE OR BIOINFORMATIC STUDIES AND STRATEGIES Over the last few years, genome-wide association studies (GWASs) have successfully identified loci associated with common diseases; however, the basis of many diseases still remains to be determined. The development of new genomic technologies has opened up the possibility of performing similar genome-wide studies to GWASs but with the aim of identifying epigenetic variations, particularly with respect to DNA methylation, that are associated with disease.

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Epigenetics in Human Disease by Trygve Tollefsbol


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