By Henry L. Foster, J. David Small, James G. Fox
Illnesses -- quantity II of The Mouse in Biomedical study. Compiles for the 1st time in a single structure a story detailing infectious illnesses of the mouse.
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Extra info for Diseases. The Mouse in Biomedical Research
Fig. 3. Left side of the nasal septum shown in Fig. 1. Cross sections of nerve fibers (N) are present deep in the submucosa. Note the hypeφlasia of the sub mucosal glands and squamoid appearance of the surface epithelium. x 3 7 5 . Fig. 4. Right side of the nasal septum depicted in Fig. 1, showing normal olfactory epithelium. Numerous large and small nerve fibers (N) are present near the bony septum. x 3 7 5 . Fig. 5. Nasal passage of a mouse with suppurative rhinitis due to Mycoplasma pulmonis.
1978; N a k a n e and 1978). Serology Since mycoplasmal infections are generally limited to mucosal and serosal surfaces, serum antibodies are usually present in low titer. T h u s , conventional serology, i . e . , c o m plement fixation, hemagglutination inhibition, and g r o w t h in hibition, has limited v a l u e , especially in early infections or latent infections w h e n the n u m b e r of o r g a n i s m s is s m a l l . T h e m o r e recently d e v e l o p e d , m o r e sensitive E L I S A ( H o r o w i t z and Cassell, 1978) r a d i o i m m u n o s o r b e n t assay ( B r u n n e r et aL, 1977), and solid phase r a d i o i m m u n o a s s a y (Taylor, 1979) m a y c i r c u m v e n t this p r o b l e m .
4. Systematic investigations of the epizootiology of M. pul monis infection are generally l a c k i n g . H o w e v e r , transmission b e t w e e n c a g e contacts as well as animals in adjacent cages has b e e n reported (Hill, 1972; N e l s o n , 1 9 3 7 a , c ) . T h u s , there is a m p l e reason to believe that offspring of infected d a m s most c o m m o n l y acquire the infection by aerosol t r a n s m i s s i o n during the first few d a y s of life ( K l i e n e b e r g e r and N o b e l , 1962; L e m c k e , 1961).
Diseases. The Mouse in Biomedical Research by Henry L. Foster, J. David Small, James G. Fox