New PDF release: Diet and Resistance to Disease

By Marshall Phillips; Albert Baetz

ISBN-10: 1461592003

ISBN-13: 9781461592006

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The primary immune response to both antigens was measured over a 2l-day period while the secondary response was also measured over 2l-day period following the second immunization-sensitization. 5 cc) followed by vaccination with a commercial L. pomona vaccine for protection against leptospirosis. Calves were-bled 6-weeks post-immunization and titered for anti-L. pomona anti-bodies. A weighted average of their data indicates more than a doubling of the average leptospirosis titers in calves given MuSe R• Aleksondrowicz (1977) has reported on the stimulation of antibody synthesis in mice and rabbits to bacterial and mycotic antigens in mice fed 50 wg of selenite/kg body weight/day supplemented to a standard ration.

In this laboratory we have recently found that the high dietary supplement of vitamin E, 300 mg/kg diet, which caused immunoenhancement and disease resistance in chicken infected with E. coli, at the same time reduced PGEl, PGE z and PGF 2a levels in the bursa and spleen (Likoff, 1978). This is shown in Figures 6 and 7. The effect was similar to that of aspirin, a known PG inhibitor. 5 0 L 0... 0 Figure 6. Prostaglandin Production in Bursa of E. coli Infected Chicks, Sacrificed 5 Minutes after Infection, and Immediately Homogenized in Aspirin Containing Buffer.

In mice, protection against Diplococcus pneumoniae (Figure 3) is well correlated with increased specific phagocytosis of the bacteria (Figure 4) and non-specific phagocytosis, the clearance of carbon particles from blood (Figure 5). DOSAGE OF VITAMIN E AND ROUTE OF ADMINISTRATION The optimal dietary dose of vitamin E in most of the reported works was between 180-360 mg/kg diet. This is approximately 3-6 times higher than the vitamin E level of currently used animal diets. , 1973). There is no firmly established optimal dose for parenteral administration.

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Diet and Resistance to Disease by Marshall Phillips; Albert Baetz

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