By Golder Wilson
This one of a kind attempt prep advisor lets you try your wisdom of crucial biochemistry and genetics suggestions for the USMLE Step 1; perform with 500 USMLE Step 1-style questions with referenced solutions; assessment factors for correct and mistaken solutions; and construct self assurance, talents, and data.
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Extra info for Biochemistry and Genetics, 2007, p.514
Rarer metabolic diseases (inborn errors of metabolism) result from specific enzyme deficiencies and exhibit autosomal or X-linked recessive High-Yield Facts 19 Figure 10 (a) Lineweaver-Burk plot of competitive inhibition. , low 1/[S] concentrations; (b) Lineweaver-Burk plot for simple noncompetitive inhibition. Note the change in Vmax with identical Km (Reproduced, with permission, from Murray RK, Granner DK, Mayes PA, Rodwell VW: Harper’s Biochemistry. 26/e. ) inheritance; accumulation or deficiency of small molecules often produces acute catastrophic disease (acidosis, seizures, coma) while accumulation of larger molecules often produces chronic disease (storage disease).
The arterial oxygen tension of blood leaving the lungs is about 100 mm Hg compared to 40 mm for veins returning blood from tissues or 20 mm within capillary beds of actively metabolizing tissues like muscle. The contrast in percent oxygen saturation between hemoglobin (~30%) and myoglobin (~90%) percent oxygen saturation in the 20–40 mm Hg oxygen tension region of the curve (the oxygen tension of peripheral tissues) illustrates that greater release of oxygen at low tensions made possible by the subunit structure of hemoglobin.
VITAMINS AND MINERALS Key concepts:Vitamins and minerals (Murray, pp 481–497. ) • Vitamins and minerals are micronutrients that generally cannot be synthesized by the body; their dietary intake must be between the extremes of low (causing clinical deficiency disease or high (causing overdose toxicity as with hypervitaminosis A or iron tablet ingestion). • The lipid-soluble vitamins A, D, E, and K are absorbed with fat, so maintenance of adequate levels require normal intestinal fat absorption; disorders causing bile acid/gut enzyme deficiencies (cystic fibrosis) or intestinal transit/brush border dysfunction (inflammatory bowel disease, chronic diarrheas causing fatty stools = steatorrhea).
Biochemistry and Genetics, 2007, p.514 by Golder Wilson