Behavioral Neuroscience of Drug Addiction - download pdf or read online

By Garret D. Stuber, F. Woodward Hopf, Kay M. Tye (auth.), David W. Self, Julie K. Staley Gottschalk (eds.)

ISBN-10: 3642030009

ISBN-13: 9783642030000

ISBN-10: 3642030017

ISBN-13: 9783642030017

Drug dependancy is a chronically relapsing psychological sickness regarding critical motivational disturbances and lack of behavioral keep watch over resulting in own dev- tation. The affliction af?icts thousands of individuals, usually co-occurring with different psychological health problems with huge, immense social and financial expenses to society. a number of many years of analysis have validated that medicinal drugs of abuse hijack the brain’s traditional gift substrates, and that power drug use motives aberrant adjustments in those rewa- processing structures. Such aberrations might be verified on the mobile, neu- transmitter, and local degrees of data processing utilizing both animal versions or neuroimaging in people following continual drug publicity. Behaviorally, those neural aberrations show up as exaggerated, altered or dysfunctional expr- sion of realized behavioral responses regarding the pursuit of drug rewards, or to environmental components that precipitate yearning and relapse in periods of drug withdrawal. present examine efforts are geared toward realizing the associative and causal relationships among those neurobiological and behavioral occasions, such that therapies will finally hire healing amelioration of neural de?cits and recovery of ordinary mind processing to advertise efforts to abstain from additional drug use. The Behavioral Neuroscience of Drug habit, a part of the Springer sequence on present issues in Behavioral Neurosciences, includes scholarly reports via famous specialists on a number of issues from either simple and medical neuroscience ?elds.

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Extra info for Behavioral Neuroscience of Drug Addiction

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57 8 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 Abstract Abuse of psychoactive substances can lead to drug addiction. In animals, addiction is best modeled by drug self-administration paradigms. It has been proposed that the crucial common denominator for the development of drug addiction is the ability of drugs of abuse to increase extracellular concentrations of dopamine in the nucleus accumbens (NAcc).

5 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 Effects of Withdrawal from Drugs of Abuse on the NAcc Dopamine System . . . . . . 1 Tonic Dopamine During Withdrawal . . . . . . . . . . . . . . . . . . . . . . . . . 2 Phasic Dopamine During (Short-Term) Withdrawal . . . . . . . . . . . . . . . . . 48 I. J. J. M. W. K. 1007/7854_2009_27, # Springer‐Verlag Berlin Heidelberg 2009, published online 15 September 2009 29 30 I.

52 7 Different Functions for Phasic and Tonic Dopamine Transmission in Addiction . . . . . 1 Dopamine Signaling in the Drug-Naı¨ve State (Fig. 2a) . . . . . . . . . . . . . . . . 2 Immediate Effects of Drug Exposure (Fig. 2b) . . . . . . . . . . . . . . . . . . . . 3 Long-Term Effects of Drug Exposure During Drug Withdrawal (Fig. 2c) . . . . . . 57 8 Summary . . . . . . . . . .

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Behavioral Neuroscience of Drug Addiction by Garret D. Stuber, F. Woodward Hopf, Kay M. Tye (auth.), David W. Self, Julie K. Staley Gottschalk (eds.)


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