Behavioral Genetics in the Postgenomic Era - download pdf or read online

By Robert Plomin, John C. Defries, Ian W. Craig, Peter McGuffin

ISBN-10: 1557989265

ISBN-13: 9781557989260

The second one writer is with the Univ. of Colorado, Boulder. offers a dialogue of genetic study on habit and specializes in cognitive talents, character, psychopathology, and psychopharmacology. Written for psychology, psychiatry, behavioral, biomedical, and organic sciences execs.

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Additional info for Behavioral Genetics in the Postgenomic Era

Example text

For this reason, the other 98% of DNA might be a good place t o look for genes associated with quantitative rather than qualitative effects on behavioral traits. Behavioral Genomics Despite the slower-than-expected progress t o date in finding genes associated with behavior, the substantial heritability of behavioral dimensions and disorders means that DNA polymorphisms exist that affect behavior. We are confident that some of the genes responsible for this heritability will be found. Although attention is now focused on finding specific genes associated with complex traits, the greatest impact for behavioral science will come after genes have been identified.

2000). Whatever the approach, ultimately the success of pooling depends on the quality (template availability) and on the accurate estimation of concentrations of the contributing DNA. Nevertheless, for those without access t o genotyping factories, pooling provides the only practical solution t o the application of association studies t o genome scans with sufficient power and marker density to detect a majority of behavioral QTLs. The Way Forward Perceptions of the field of behavioral genetics have changed radically over the past decades.

Cheek swabs yield enough DNA to genotype thousands of genes, and the cost of genotyping is surprisingly inexpensive. It is crucial that the behavioral sciences be prepared to use DNA in research and eventually in clinics. What has happened in the area of dementia in the elderly population will be played out in many other areas of the behavioral sciences. The only known risk factor for late-onset Alzheimer’s dementia (LOAD) is a gene, apolipoprotein E, involved in cholesterol transport. A form of the gene called allele 4 quadruples the risk for LOAD but is neither necessary nor sufficient to produce the disorder; hence, it is a QTL.

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Behavioral Genetics in the Postgenomic Era by Robert Plomin, John C. Defries, Ian W. Craig, Peter McGuffin


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