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Extra resources for Aspirin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Other experiments will use animal models of insulin resistance to address the pharmacological profile for IKKb inhibition in vivo using various salicylates, and to directly determine the target of salicylate-mediated insulin sensitization. Finally, clinical studies are proposed to determine whether IKKb inhibition reverses insulin resistance in humans with impaired glucose tolerance. ; Assistant Professor of Medicine; Medicine; Baylor College of Medicine 1 Baylor Plaza Houston, Tx 77030 Timing: Fiscal Year 2002; Project Start 30-SEP-2002; Project End 31-AUG-2007 Summary: (provided by the applicant): Atrial fibrillation is a common disorder and an important risk factor for stroke.
Since February 1995, Dr. Shuldiner and his coworkers have recruited and studied over 2500 Amish individuals, 1,000 of whom are participants of Amish Family Calcification Study (AFCS), a study designed to examine independent 28 Aspirin and joint genetic influences on osteoporosis and coronary artery disease. Extensive phenotypic characterization of AFCS participants include blood pressure, body composition, bone mineral density, lipids, and coronary artery calcification by electron beam CT. DNA already has been collected on all AFCS subjects and a 5-cM genome scan (approximately 800 short tandem repeat (STR) markers) will be completed by Summer 2002.
Insulin signaling studies conducted with tissues isolated from the rodents show that insulinstimulated Tyr phosphorylation of IR and IRS are increased due to decrease in inhibitory Ser/Thr phosphorylation of IRSs. Heterozygous deletion (IkkBeta +/-) in 38 Aspirin mice reduced fasting glucose and insulin concentrations, and protected against the development of insulin resistance during high-fat feeding and in obese Lep-ob/ob mice. We also found that obese animals have higher IKK kinase activity than control animals.
Aspirin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Health Publica Icon Health Publications