By John G. Bartlett MD
Designed to supply easy access to criteria of deal with infectious illness via targeting choice, right doses, charges, and negative effects of antimicrobial brokers, the 2005-2006 notebook of Infectious sickness Therapy attracts broadly from ideas made by means of the facilities for illness keep an eye on and Prevention, the clinical Letter on medicinal drugs and Therapeutics, and from legitimate statements of revered clinical societies. Tabular fabric has been up-to-date to incorporate all newly licensed antibiotics, in addition to new concepts for management.
This version contains topical matters reminiscent of MRSA (USA three hundred strain), Avian influenza, Acinetobacter Hepatitis B virus (HBV), hepatitis C virus (HCV), and bioterrorism. It additionally includes the hot instructions for pyogenic meningitis, diabetic foot infections, healthcare linked pneumonia, surgical prophylaxis, fungal infections, bacteruria, and administration of infections linked to foreign travel.
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Additional resources for 2005-2006 Pocket Book of Infectious Disease Therapy
85 Pitfalls and notations with calculations follow. a. Elderly patient: Serum creatinine may be deceptively low (with danger of overdosing) because of reduced muscle mass. b. Pregnancy, ascites, and other causes of volume expansion: GFR may be increased (with danger of underdosing) in third trimester of pregnancy and patients with normal renal function who receive massive parenteral fluids. c. Obese patients: Use lean body weight. d. Renal failure: Formulas assume stable renal function; for patients with anuria or oliguria assume creatine clearance (CCr) of 5-8 mL/min.
Oral cephalosporins; cefuroxime has both oral and parenteral formulations. † Telithromycin is also active agent against multi-drug resistant Streptococcus pneumoniae. 41 ANTIMICROBIAL DOSING REGIMENS IN RENAL FAILURE A. GENERAL PRINCIPLES 1. Initial dose is not modified in renal failure. 2. Adjustments in subsequent doses for renally excreted drugs may be accomplished by a) giving the usual maintenance dose at extended intervals, usually three half-lives (extended interval method); b) giving reduced doses at the usual intervals (dose reduction method); or c) a combination of each.
Pyogenes—see pp 241, 245) (CID 2002;35:113) Pharyngitis Soft tissue infection Pneumonia (see p 253) Abscesses Penicillin G or V (if penicillin-resistant S. pneumoniae—see below) Cephalosporin (1st gen), cefuroxime, cefotaxime, ceftriaxone; Erythromycin, clarithromycin, azithromycin Vancomycin; clindamycin; tigecycline Endocarditis Penicillin G ± streptomycin or gentamicin Cephalosporin: Parenteral—see above vancomycin Beta-lactams S. saprophyticus S. epidermidis S. iniae S. pneumoniae (see p 253) Bacteremia, cellulitis Penicillin, clindamycin Meningitis (see p 233) Ocular infections Vancomycin + cefotaxime or ceftriaxone Cefotaxime; ceftriaxone (activity variable) S.
2005-2006 Pocket Book of Infectious Disease Therapy by John G. Bartlett MD